Saturday, May 23, 2020

Launching a New Product - Idioms in Context

This short story focuses on the difficulties of launching a new product, or introducing a new idea. Learn from the definitions provided for the idioms and expressions introduced following the story and check your understanding with a short quiz. Make sure to read for gist the fist time. Launching a New Product - Story Trying to launch a new product can be a daunting task. In fact, its so hard that most people have no staying power and soon give up realizing that theyll have to cut their losses and accept defeat. There are many reasons for these difficulties, not least of which is that really new ideas often fly in the face of most peoples expectations. Just think back to the days before the cell phone. Im sure the company that created that first huge, heavy portable phone faced a lot of opposition to their product. Who ever thought wed end up carrying phones in our pockets that have also double as our personal digital assistants?!   In order to keep the ball rolling, an entrepreneur or anyone with a new idea will probably have to ruffle peoples feathers as the push for success. This ability to tilt at windmills is similar to the ability to completely ignore what, at the time, must seem like obvious advice. Its this knack for belief in spite of doubt that success hinges on. Without an almost religious conviction, its hard to continue with the order of the day of pushing your product. This is especially true when a CEO or some other important corporate know-it-all is looking daggers at you as they rake you over the coals for ever having thought of such a stupid idea. Then of course, there are those who throw a red herring into the conversation as you make your pitch to potential investors. However, in the end, you wont need to hard sell your product to those who get it. Theyll recognize your inspiration and throw caution to the wind to catch the train of your genius! Thats the day youll kick off your drive to succ ess. Definitions cut ones losses - accept that you have lost and quitfly in the face of something - be contrary to what some ideas seem to provehard sell something - try to force someone into buying something by making them believe that they need to buy it NOW!have no staying power - not be able to last a long timehinge on something - be dependent upon something else happeningkeep the ball rolling - continue supporting something by doing what is necessarykick off - begin something, usually some sort of business campaignlook daggers at someone - look at someone with intense hatredmake a pitch - introduce a business idea to someone, try to sell somethingorder of the day - the most important thing that needs to be done on an agendarake someone over the coals - strongly criticize someone for doing something wrongred herring - an argument which is introduced into a discussion to avoid talking about something more importantruffle someones feathers - insult someonethrow caution to the wind - take a chance d espite the risktilt at windmills - work against impossible odds, try to continue doing something that is hindered by others Idioms Quiz Lets keep ______________ on this project. I dont think we should quit just yet.Any artist will tell you that before success comes youll often feel as if are ______________.He had to accept defeat, ______________ his ______________ and close the business.  She ______________ her husband ______________ for his mistakes that cost them thousands.Im afraid that idea has ______________. Itll never work out.Stop ______________ me! I didnt do anything wrong, and I didnt mean to offend you.Peter knew that he was bringing a ______________ into the conversation, but he didnt want the project to move forward.Im afraid that ______________ everything I know. It cant be true.  Our success ______________ getting an investment in this project. Without funds, were lost.  Id like to ______________ at the next investors meeting. Do you think theyll have time to listen to my proposal? Quiz Answers the ball rollingtilting at windmillscut his lossesraked her husband over the coalslooking daggers atred herringflies in the face ofhinds onmake a pitch Learn more idioms in context with further stories.

Monday, May 18, 2020

Analyzing The Project Execution, Reporting, And Managing...

Examining the project execution, reporting, and managing resources for ECO-Trans will show where the companies project could benefit. ECO-Trans is a company based in Europe that provides a driver assist technology used on buses, trains, and other mass transit vehicles. Their new product allows for a better driver performance that analyzes routes and advises the worker on which patterns to use resulting fuel savings. The case study analysis will show where fault and area for improvement. The project management fundamentals that are targeted are in the schedule, cost, conflict resolution, team management, communication with stakeholders, and resource allocation. The project success ultimately relies on the project manager ability to use all tools and techniques associated with a project s progress. The key to providing a project within the schedule and allocated budget are essential issues for a project s success. The project manager must continually monitor and regulate project objectives to stay inside the budget and on time. The manager has to identify early indicators that could potentially risk or derail the project and take the required counteractive action keeping the assignment under control. The first obstacle to figure out is the schedule. Since the project s sponsor mandated that the project must be delivered on time and within budget. However, the project has run into some hindrances creating delays; mainly the delivery of defective computer terminalShow MoreRelatedProject Mgmt296381 Words   |  1186 PagesReference of Project Management Body of Knowledge (PMBOK) Concepts to Text Topics Chapter 1 Modern Project Management Chapter 8 Scheduling resources and cost 1.2 Project defined 1.3 Project management defined 1.4 Projects and programs (.2) 2.1 The project life cycle (.2.3) App. G.1 The project manager App. G.7 Political and social environments F.1 Integration of project management processes [3.1] 6.5.2 Setting a schedule baseline [8.1.4] 6.5.3.1 Setting a resource schedule 6.5.2.4 Resource levelingRead MoreContemporary Issues in Management Accounting211377 Words   |  846 PagesSheffield (1981–2) and Sydney University (1983–5). She teaches and researches in the area of management accounting. Her current research projects include an examination of the role of financial and nonfinancial controls in the management of strategic supply relationships, knowledge management in professional service firms, and the effects of extended performance reporting on financial markets. She has published widely in international journals including The Accounting Review; Accounting, OrganizationsRead MoreLibrary Management204752 Words   |   820 PagesChan Developing Library and Information Center Collections, Fifth Edition G. Edward Evans and Margaret Zarnosky Saponaro Metadata and Its Impact on Libraries Sheila S. Intner, Susan S. Lazinger, and Jean Weihs Organizing Audiovisual and Electronic Resources for Access: A Cataloging Guide, Second Edition Ingrid Hsieh-Yee Introduction to Cataloging and Classification, Tenth Edition Arlene G. Taylor LIbRaRy and InfoRMaTIon CenTeR ManageMenT Seventh Edition Robert D. Stueart and Barbara B. Moran Read MoreMedicare Policy Analysis447966 Words   |  1792 Pagesand Mr. ANDREWS) introduced the following bill; which was referred to the Committee on Energy and Commerce, and in addition to the Committees on Education and Labor, Ways and Means, Oversight and Government Reform, the Budget, Rules, Natural Resources, and the Judiciary, for a period to be subsequently determined by the Speaker, in each case for consideration of such provisions as fall within the jurisdiction of the committee concerned A BILL To provide affordable, quality health care forRead MoreOrganisational Theory230255 Words   |  922 PagesBrigham, Lancaster University, UK McAuley et al. provide a highly readable account of ideas, perspectives and practices of organization. By thoroughly explaining, analyzing and exploring organization theory the book increases the understanding of a field that in recent years has become ever more fragmented. Organization theory is central to managing, organizing and reflecting on both formal and informal structures, and in this respect you will find this book timely, interesting and valuable. Peter HoldtRead MoreStephen P. Robbins Timothy A. Judge (2011) Organizational Behaviour 15th Edition New Jersey: Prentice Hall393164 Words   |  1573 PagesSingapore Taipei Tokyo Editorial Director: Sally Yagan Director of Editorial Services: Ashley Santora Acquisitions Editor: Brian Mickelson Editorial Project Manager: Sarah Holle Editorial Assistant: Ashlee Bradbury VP Director of Marketing: Patrice Lumumba Jones Senior Marketing Manager: Nikki Ayana Jones Senior Managing Editor: Judy Leale Production Project Manager: Becca Groves Senior Operations Supervisor: Arnold Vila Operations Specialist: Cathleen Petersen Senior Art Director: Janet Slowik Art

Monday, May 11, 2020

Personal Experience Home Made Fertilizer and Inorganic...

Introduction: My family and I do a lot of traveling and while traveling we pass through rural communities where the people have to grow their own food as they do not have enough income to buy their own food. Some of these people, however, still use fertilizer in order to increase the rate of production and total yield produced. Those people who use a form of fertilizer to feed their plants, they generally use cattle manure or home-made fertilizer. At home we used to use inorganic fertilizers on our plants as they are easier to use and easily available at any garden shop, however, we have started to use the new Bokashi medium as fertilizer as it is better for the environment and it also reduces food waste. Food waste is reduced as the leftover food is used to create a liquid which can be used as a fertilizer as it is full of the nutrients left in the leftover food. I started to think about which fertilizer would work best: According to my research on the difference between inorganic and organic f ertilizers, the organic fertilizers work so well because they supply the plants with the nutrients required for growth immediately. However, the organic fertilizers such as cattle manure work so well because they enrich the soil with humus allowing for nutrients to form naturally, which will last. I was interested in which of these fertilizers would produce the best crop in a set period of time, as this would help figure out which fertilizer is best to use in the garden. ResearchShow MoreRelatedHow Food Security And Hunger Are Huge Issues3133 Words   |  13 Pagescrisis of overpopulation, overconsumption, food loss, wastage and scarcity of natural resources like water, food and fuel for survival. Yet, many are still unaware about the significance of the problem. Although, technology has improved our lives and made things a good deal easier and convenient for us, however, it has not solved the questions of how to sustainably use the resources. This paper will further address the mo dern industrial agriculture practices that have caused negative impacts on theRead MoreOrganic Food8071 Words   |  33 Pagescultivating foods and other agricultural products using methods that do not involve modern synthetic inputs such as synthetic pesticides and chemical fertilizers, do not contain genetically modified organisms, and are not processed using irradiation. Organic food is produced with: †¢ No synthetic pesticides, herbicides or fumigants †¢ No fertilizers made with synthetic ingredients or sewage sludge †¢ No genetically modified organisms (GMOs) †¢ No irradiation †¢ No hormones, antibiotics, artificialRead MoreThe Antimicrobial Effect of 100% Mature Psidium Guajava (Guava) Leaf Extract on the Growth of Pseudomonas Aeruginosa (Atcc # 27853)5916 Words   |  24 Pages The guava extract will be weighed to get 100 g. Sterile distilled water will be added to the extract to make a 100 mL solution, which is equivalent to 100% concentration. Preparation of Filter Paper Disk Whatman Filter Paper No. 2 disks will be made with an approximate diameter of 6.6 mm by using an ordinary office two-hole puncher. Precaution must be taken to avoid overlapping of holes, since the paper disks will have a tendency to curl after punching. They will be flattened by spreading themRead MoreAn Introduction to Hydrophonics and Controlled Environment Agriculture40110 Words   |  161 Pagesnatural environment to an artificial one†¦ using protected agriculture and/or greenhouses. Modify or control the temperature, relative humidity, CO2, light, etc., to provide optimum conditions to grow any crop any time anywhere! What discoveries had to be made in order to develop the modern greenhouse? *1385 – The French built â€Å"glass pavilions† oriented toward the south to grow flowers (though mainly for the wealthy to enjoy!). *1500’s and 1600’s – The expanding glass industry in Italy probably promptedRead More International Trade And Development Report Essay3465 Words   |  14 Pagesthe New Zealand markets. For New Zealand the tariff for the agricultural product is so high in the percentage of 35%. Higher tariff value has made the products of New Zealand non-competitive to the competitor’s products. The free trade agreement between these two countries will play a major role in increasing the trade between these two countries. India has made many trade agreements, which are Asia pacific Trade agreement (APTA), Bhutan India agreement on trade commerce and transit, India-MaldivesRead MoreCountry Note Book of China17054 Words   |  69 PagesHeilongjiang has an average January mean temperature of below  Ã¢Ë†â€™20  °C  (−4  Ã‚ °F), and the reading may drop to  Ã¢Ë†â€™40  °C  (−40  Ã‚ °F); the average July mean in the same area may exceed  20  °C  (68  Ã‚ °F). By contrast, the central and southern parts of Guangdong province experience an average Ja nuary temperature of above  10  °C  (50  Ã‚ °F), while the July mean is generally above  28  °C  (82  Ã‚ °F). C. Topography writing guide The  topography  of China has been divided by theRead MoreBiology Ecology Project22611 Words   |  91 Pagesinhabited by life—and can provide the basic understanding that will help us conserve and sustain that richness, now threatened more than ever by human activity. The richness is particularly apparent in tropical forests, such as the Panamanian forests, home to the Hercules scarab beetle (Dynastes Hercules). Picture shows the Dynastes hercules Humans have always had an interest in the distribution and abundance of other organisms. As hunters and gatherers, prehistoric people had to learn whereRead MoreBhopal Gas Disaster84210 Words   |  337 Pagesin-depth understanding of the issues see www.indiaenvironmentportal.org.in/indepth/term/2542. A comprehensive collection of these up-to-date news clippings, research papers, lab studies, reports, documents, opinions and court judgments etc have now been made available by the Centre for Science and Environment at www.indiaenvironmentportal.org.in/taxonomy/term/2544. Links to selected CSE research papers and lab report. http://www.downtoearth.org.in/webexclusives/factsheet_1.htm http://www.indiaenvironmentportalRead MoreImpact of Science on Society38427 Words   |  154 Pagesoutstanding television writers, hosts, and producers. Born in Northern Ireland and educated at Oxford University, Burke spent 5 years in Italy teaching at the Universities of Bologna and Urbino and directin g the English Schools in Bologna and Rome. He made his television debut in 1965 as a reporter for Granada Television’s Rome Bureau. Burke’s impressive following in the British Isles dates back t o 1966, when he joined the BBC’s weekly science show, Tomorrow’s World. As the chief BBC correspondent forRead MoreImpact of Science on Society38421 Words   |  154 Pagesoutstanding television writers, hosts, and producers. Born in Northern Ireland and educated at Oxford University, Burke spent 5 years in Italy teaching at the Universities of Bologna and Urbino and directing the English Schools in Bologna and Rome. He made his television debut in 1965 as a reporter for Granada Television’s Rome Bureau. Burke’s impressive following in the British Isles dates back t o 1966, when he joined the BBC’s weekly science show, Tomorrow’s World. As the chief BBC correspondent for

Wednesday, May 6, 2020

Summary Of The Hunt - 851 Words

The Hunt It was four a.m. on November 4, 2013 when the day of hunting began. My dad was abruptly yelling in my room to go take my de-scenting shower. I really did not want to go, and I wouldn’t have if the day wasn’t predicted to be the best day for hunting. We were going deer hunting for a trophy buck. With the little energy I possessed, I crawled out of bed. As I stood up from my cozy nest of slumber my eyes went black from moving too quickly. When I regained my bearings, I made my way to the refrigerator to get a glass of water. Upstairs my dad’s shower was running and I knew I was going to be late. He always had enough time to get his 3-layers of clothes on and watch TV before I even get in the shower. My dad tells me that it’s his normal routine where he has to get up early every morning for work. For me, school comes early enough and 7 a.m. is hard for me to wake up, much less four. When I was finally ready to leave, inside the house I was sweating from all t he heat I had built up, but outside I was grateful to have it. Our hunting property is located in Crockett, Virginia which is about 20 minutes from my house. The road was empty and carefully unfolded as our truck lights shinned to unveil it. I was trying to soak up heat from the truck to embrace the cold outside. When we finally reached our destination, I had to leave my comfort in the heat behind in the truck, put on another layer of clothes, and off we went to our tree stand. My father and I were going to a treeShow MoreRelatedInterview Summary – Tessy Hunt. This Interview Process1244 Words   |  5 PagesInterview Summary – Tessy Hunt This interview process really taught me how to listen to and accept the viewpoints of other people who are not necessarily from the same background that I am from. I spoke to one person that I have known for years, and another person who I never spoke with prior to the interview. My first contact was Ms. Tessy Hunt, a direct support counselor for individuals with special needs. The people who Tessy serve, face challenges that not everyone is equipped to support. I choseRead MoreCase Analysis : Wearne And White Hunt 1025 Words   |  5 PagesCase Study Summary Overview Philosopher William James once stated, â€Å"acceptance of what has happened is the first step to overcoming the consequences of any misfortune† (n.d.). For New York and the world, this acceptance of the terrorist attacks on September 11th would take a back seat to a more pressing concern; the search for survivors or their remains. A task made harder by the sheer nature of the disaster. â€Å"The wreckage was a precarious mess of twisted steel, concrete and debris, which couldRead MoreThe, And The Clay Hunt Suicide Prevention For American Veterans Act Of 20141524 Words   |  7 Pagesto grow and change overtime, recent reforms have been set in place to continue to provide healthcare to veterans. This paper will discuss a brief summary of recent reforms of the Veteran Access, Choice, and Accountability Act of 2014 (H.R. 3230) and the Clay Hunt Suicide Prevention for American Veterans Act of 2014 (Clay Hunt SAV Act). From this summary it will then be appropriated how these ref orms adhere to the social justice framework presented by John Rawls in the Rawlsian â€Å"Justice as Fairness†Read More5-Day Lesson Plan1065 Words   |  5 Pages (ocean, sea, theory, freshwater, salinity, lake, river, underground water, oceanography). Student groups will complete â€Å"Label the Earth’s Oceans†. CLOSURE: Review and discuss oceans. 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Student life could promote the scavenger hunt and assist with the execution of the events. The goal is to help students become familiar with the program throughout each semester. Towards the last three months of each semester, we will have an event to test the student’s skills and knowledge they acquired through the activities. The Scavenger hunts consist of three online challenges. The student who can complete the scavenger hunt in the least amount of time willRead MoreCase Study : Sydney Cloud Case1052 Words   |  5 PagesSydney Cloud Case Study Business Law 3310 Dr. Stanley F. Seat Name and Citation Contract Freighters, Inc., V. J.B. Hunt Transport, Inc. 245 F.3d 660, 52 ERC 1349 Decided on April 3, 2001 Court This decision was held at the district level with the Honorable Gary A. Fenner of the United States District Court of the Western District of Missouri as the judge on the case. Judicial History In order to determine which party to rule in favor of, the court must look back to prior rulings to discoverRead MoreDetection Capabilities Of Endpoint Antivirus Solutions1235 Words   |  5 Pagesattacker can persist for long periods of time by adding more user and system accounts. By proactively deploying continuous data collection to track an attacker’s every move, and classifying threats by leveraging robust threat intelligence, enterprises can hunt across the attacker’s entire kill chain. The example below also illustrates the shortcomings of endpoint visibility provided by most security solutions. With no reputation or threat intelligence data to draw on, how do enterprises pick the needlesRead MoreBipedalism : What Is That All About?1114 Words   |  5 Pagesthe idea that bipedalism was born out of a necessity for early hominids to take care of their families. He speaks about the need for provisioning and how bipedalism allowed early hominids to carry necessary resources by hand (Lovejoy 1981). In his summary he speaks about â€Å"five characters [which] separate [us (H. s. sapiens)] from other hominoids† (Lovejoy 1981), those being our use of bipedal locomotion, a reduction in size of our front teeth with an emphasis on molars, â€Å"material culture† (LovejoyRead MoreBio 100 Appendix E Essay999 Words   |  4 PagesAxia College Material Appendix E Pearson Lab Scavenger Hunt In Week Three through Week Eight, you conduct scientific experiments in an online lab environment. The content of the labs vary with each week but the structure remains the same. This week, review your Week Three lab instructions and assignment to become acquainted with the essential elements of each lab. You are not required to complete the actual lab this week, but rather to locate various pieces of information about the labs to help

First Year Experience Free Essays

English 1301 Professor Terri Craig 20th March 2018 Registration Day Welcome to Lonestar Cy fair for the spring semester of 2018 all new and incoming first year college students. We here at Lonestar wish nothing but the best for you in your academic careers; while pursing your degree, in whatever that may be. Today will be your first introduction into the Lonestar college and registration system. We will write a custom essay sample on First Year Experience or any similar topic only for you Order Now The registration process may seem overwhelming at first but that is simply because you have never had an experience like it before. Once you understand how everything operates around here, you will realize how simple and easy registration really is. I will be going over deciding your major, choosing your classes, and setting up financial aid. Everything will be explained in detail so that there will not be any confusion along the process. First things first, you all want to have a major so that you all do not waste your time. Everyone is not expected to know exactly what they would like to major in, so having an idea is also fine. To anyone who is unsure on their major you can meet up with any of our advisors here at the school free of charge Monday through Friday. They will dig into your personality a bit, asking you various questions such as are you more of an introvert or extrovert, also your preferences to point you in the right direction of what to major in. The advisors will also help students decide on which classes to take to reach the ultimate goal of graduating. Deciding on a major is important for two reasons when first starting off college. Reason one being that you all do not want to waste your time chasing a career path that does not suit you or you do not enjoy. Secondly, in order to pick your classes accordingly, you have to have a major. Having a major brings me into my second topic, which is picking your classes.Picking your classes will be the easiest task you have on registration day. You all will choose your classes in the enrolment lab; the Enrollment Lab is a computer lab located on the first floor and is available to students who need assistance. During this process you will be able to decide on the days, time, and types of classes you wish to take. Do you want to have class in a classroom or online? Or do you want to have a mixture of both? Are you a morning person who can function or do you prefer to sleep in and have class later in the day? You have the option to pick and decide how you want to approach your classes. If you would like to know more about your potential professor, you can look up the different reviews they have to decide if they best match your learning style. Once you have decided on your classes, all you have to do is register and you are good to go. Its best to pick classes that day because they will often fill up quickly. Now that you all have decided on your major and which classes to go along with that, you need to check in with financial aid.Financial aid is not a requirement for everyone who attends college, but for most it is a major help. If you are interested in financial aid, save yourself the hassle and have everything you need prepared before you go, to save yourself a bit of time. Financial aid is funding available to students to assist with the completion of academic programs if you qualify for it. This includes student loans, scholarships, and work study programs just to name a few. It is best to go early to the financial aid office because it is often the busiest on registration day. Registration day is always confusing for any new comer into any college system. However, as you can tell the, registration process is not that difficult at all. Once you decide on a major, the other steps just come naturally. I hope you all find it simple and easy to navigate around the school on registration day. How to cite First Year Experience, Papers

Colorectal Cancer for Inflammatory Bowel Disease - myassignmenthelp

Question: Discuss about theColorectal Cancer for Inflammatory Bowel Disease. Answer: Colon and rectum tumors are mostly common; the colorectal area is now the third most common site of cancer cases and deaths globally (Bailey and You, 2014). Cancer of the colon and rectum develops from the epithelial lining of the intestine. It usually begins as a benign polyp which later becomes a malignant which penetrates and destroys the normal tissues. The frequency of occurrence is highest for individuals older than 85 years of age and is higher for individuals who have had a history of colon cancer in the family. The specific cause of colorectal cancer is still not known but the risk factors have been identified. The risk factors include breast cancer in women, high fat and beef intake, and medical record of inflammatory bowel disease and lastly family history of colon cancer (Ponteri-lewis, 2013). If this disease is detected early and treated, it could save three people out of four with colon cancer. This essay is going to talk about the drugs administered to Nelly their mech anism of action and lastly the technologies used to detect colorectal cancer. Drugs administered Colorectal cancer therapy depends on the stage of the disease and it usually done by removal of the tumor through surgery, adjuvant therapy and supportive therapy. Nellie had a stage IVA cancer and she was referred to a colonoscopy and it was discovered that nelly had polyps in the colon which were surgically removed. She later came for adjuvant therapy which included 5-Fluorouracil, Irinotecan and lastly Oxaliplatin. This kind of therapy was used to reduce the chances of the cancer coming back after surgery. Pain medication was initiated after targeted radiotherapy failed to shrink the tumor, the severe back pain was as a result of cancer that had spread to the spinal cord and was compressing the spinal cord. Pain medication included paracetamol and morphine. Spinal tumor increased each day which caused more pain and the dose of morphine was difficult to titrate due to severe side effects it caused. End of life pathway drugs were commenced which included levomepromazine and sublingu al clonazepam. Mechanism of action 5- Fluorouracil (5-FU) is an antimetabolite which exerts its action on cells undergoing cycling. It kills tumor cells which are in the cycling and resting phase of the cell cycle. In the cell fluorouracil is changed to 5- fluoro-2-deoxyuridine-5-monophosphate (5-FdUMP), which causes the suppression of thymidylate synthase which later leads to the death of thymineless of cells. DNA synthesis is inhibited by the penetration of FdUMP. RNA synthesis and function is inhibited by 5-fluorouradine-5-triphosphate (FUTP) which is a fluorouracil metabolite. In the tumor cell the mechanism of resistance include an increased thymidylate synthase activity, a reduced activation of 5-FU, and lastly a decreased drug sensitivity of this enzyme. As a result the cell is unable to divide and dies. Irinotecan is a plant derived cell cycle specific (CCS) drugs which is found in the camptothecins group. It is converted to an active form SN-38 which requires carboxyl esterase (Huangg, Wuerzberger-Davis and Seufzer, 2012). it inhibits topoisomerase 1 activity hence causing damage to the DNA. The DNA is damaged by an inhibiting enzyme that cuts and the single DNA strands during the normal DNA repair process (Maureen, Beidler and cheng, 2013). Oxaliplatin is a chemotherapeutic agent that contains 1, 2- diaminocyclohexane ligand. Like the other platinum based compounds it exerts its effect by damaging the DNA and also by inhibition of RNA synthesis. It induces three types of links which include DNA intra-strand link, DNA inter-strand crosslinks and DNA-protein crosslinks. Intra-strand links act by the induction of DNA lesions while the inter-strand link are said to bring about the cytotoxicity of cisplatin. The DNA protein crosslink causes arrest of DNA synthesis and inhibition of messenger RNA synthesis hence cell death. Paracetamol also known as acetaminophen is a weak inhibitor of cyclooxygenase-1 (COX-1) and COX-2 are inhibitors of prostaglandin (Boataud, Aronoff and Richardson, 2015). Prostaglandin is inhibited if there is a low level of arachidonic acid. Cox-2 is the main isoenzyme when the arachidonic acid is at low concentration (Aronoff, Boutard and Marnett, 2013). And for this reason paracetamol selectively prevents prostaglandin synthesis involving Cox-2 this is due to the lower flux in the pathway that produces decreased level of hydroperoxide. Opioids acts on the receptors found in neuronal cell membrane to produce effect. The major three types of receptors include kappa, delta, and mu. Morphine has been found to have a high affinity for m receptors. G-protein which is a guanine nucleotide protein is coupled to opioid receptors. The opioid has two sites where it acts upon, the postsynaptic neuron and the presynaptic nerve terminal. In the presynaptic nerve terminal the action of morphine is to prevent neurotransmitter release by reducing calcium entry and increasing potassium current. Morphine also acts on the pain pathways, opioid receptors are present in pain transmission regions of the nervous system. It acts by inhibition of neurotransmitter release from the primary afferent terminals found in the spinal cord and also the activation of the midbrain control that is the descending inhibitors. Levomepromazine is a neuroleptic agent. It has anti-histamine, anti-emetic and analgesic effect. It precise mechanism of action is not yet known. Clonazepam is a benzodiazepam. It is a strong anticonvulsant. Its main type of action is to make it easier for GABAergic transmission in the brain. This GABA receptors are located in dorsal raphe neurons which acts by inhibiting raphe cell lining. 5-HT synthesis is not inhibited by clonazepam but it reduces the utilization of 5-HT in the brain. Technologies used to detect colorectal cancer Colonoscopy is a procedure in which one views the large intestine using a device known as a colonoscope (Zapka, Klabunde and Typlin, 2014). It is a thin flexible tube with a camera and a source of light. This device is inserted in the anus region and through the colon. This device captures images and videos for the doctor to see. If there is an abnormal growth the doctor will be able to see. It is also used to remove little amount of tissue for biopsy. DNA testing has been used to identify individual at risk of colorectal cancer. Through DNA testing doctors have been able to prevent the disease at an early stage. Clients identified at risk are genetically cancelled on the disease, so as to understand prevention and treatment measures (Leissic, 2012). Stool test has been used to check for the presence of blood. It is the most common method used for early cancer detection (Burch, Soares-Weiser and John, 2013). The basic examination of the stool includes checking for color and testing for occult blood. It also checks for the ion containing portion of the hemoglobin known as the heme which is changed during the movement in the intestines (Ouyang, Chen and Getzenberg, 2018). Lower gastrointestinal tract procedure has been used to detect the presence polyps and tumors in the colon. Barium enema is inserted in the rectum so as to visualize the presence polyps. This radioscope substance is inserted during fluoroscopy. Other visualizing colon studies include double contrast studies. In double contrast, it involves the insertion of thick barium solution followed by pumping of air. This process distinguishes barium coated mucosa and air filled lumen hence allowing easier detection of little lesions. Sigmoidoscopy, anoscopy and protoscopy are used to view the lower portion of the colon to check for rectal bleeding, tumor, polyps or other pathological processes. The anoscope is used to view the anus and the lower rectum. The sigmoidscopes and protoscopes are rigid scopes used to view the rectum and sigmoid (Elmunzer, Harvard and Schoenfeld, 2015). The flexible fiberoptic sigmoidoscope allows the colon to be viewed up to 40-50cm from the anus. During the procedure biopsy can be performed using a small biting forceps introduced through the endoscope. If the rectal polyps are viewed that can be removed with a wire snare used to grasp the pedicle. Magnetic resonance imaging is used in the checking of polyps in the colon (Forsberg, 2012). This is a non-invasive technique that uses radio waves and magnetic fields to produce an image of the area being studied. Oral contrasts agents are used to enhance images. The client lie in the machine having not eaten or drunk anything for the last 6-8 hours. The entire procedure takes up to thirty to ninety minutes. Scintigraphy is a radionuclide testing which uses the radioactive isotopes such as the indium and iodine. This agents are used to reveal or visualize changes in atomic structures, organ size and the presence of neoplasm or any other focal lesion. Abdominal ultrasonography is another method used to check polyps in the colon. This is done by production of high frequency sound waves in the internal body organs. This echoes are recorded on an olliscope as they pass through the tissues. This method is used to check the size of and the configuration of abdominal structures. Advantages of this method is that it needs no ionizing radiation hence they will be no side effects and it also not expensive. The only disadvantage that it has is that it cannot view structures behind a bone since the bone prevents ultrasonic echoes from passing to the deeper structures. References Aronoff, D., Boutard, O. and Marnett, J. (2013). Inhibition of prostaglandin H2 synthases by salicylate is dependent on the oxidative state of the enzymes.J. Pharmacol. Exp. Ther, 304, pp.589-594. Bailey, E. and You, N. (2014). Increasing disparities in the age related incidence of colon and rectal cancer in the United States. 150(1), pp.17-22. Boataud, O., Aronoff, D. and Richardson, J. (2015). Determinants of the cellular specificity of acetaminophen as an inhibitor of prostaglandin H2 synthases.Proc. Natl. Acad. Sci. USA, 99, pp.730-735. Burch, T., Soares-Weiser, K. and John, D. (2013). Diagnostic accuracy of fecal result blood tested in screening colorectal cancer: A systemic review.journal of medicine screening, 14(3), pp.132-137. Elmunzer, B., Harvard, R. and Schoenfeld, P. (2015). Effect of flexible sigmoidoscopy based screening on incidence and mortality of colorectal cancer: A systematic review and meta-analysis of randomized controlled trial.Plus Medicine, 9(12), pp.1001-1035. Forsberg, F. (2012). Advance in ultrasound contrast technique.Applied referencing radiology, 16, pp.5-10. Huangg, T., Wuerzberger-Davis, S. and Seufzer, B. (2012). NF-Kaapab activation by capmtothelin, a linkage between nuclear DNA damage and cytoplasmic signed events.J clin invest, 107, pp.241-246. Leissic, M. (2012). Advance in genetic testing for care risk.Medsurge nursing, 10(3), pp.123-125. Maurren, J., Beidler, R. and cheng, Y. (2013). Campthocesin resistance related to to drug induced down regulation of topoisomerase 1 and steps occurring after the formation of protein linked DNA breaks.AnnNy Acad Sci, 803, pp.74-92. Ouyang, D., Chen, J. and Getzenberg, R. (2018). Non-invasive testing for colorectal cancer: A review.American journal of gastroentology, 100(6), pp.1393-1403. Ponteri-lewis, V. (2013). Colorectal cancer.Medsurge nursing, 9(1), pp.9-15. Zapka, J., Klabunde, C. and Typlin, S. (2014). Screening colonoscopy in the USA: Attitudes and practises of primary care physians.Journal of general intervid medicine, 27(9), pp.1150-1158.

Friday, May 1, 2020

Personal Narrative Being Fully Human perso Essay Example For Students

Personal Narrative Being Fully Human perso Essay nal narrative essaysBeing Fully Human One act of simple human kindness can make a real difference. For example, one can make a short and tender call to an acquaintance and save this persons future career or even hisher life during that call. A few weeks ago from the innermost of my heart, I felt a premonition. Which I felt my heart was passing a message to me: call your friend who is studying in London for her degree. At that moment I suddenly realized that I had not contacted her for at least six months, which is not the correct way to treat friends. Nevertheless, I am glad that I made this phone call to her, as we are old friends. However, on the other hand I was given her bad news. She told me unspeakable things; she was being deceived by her boyfriend, as well as has asked to leave their little lovely flat immediately. Besides these ugly things, the upper most thought in my mind was she might fell abandoned by society, and do something unimaginable to herself, like give up her studies, or even to put an end to her young and beautiful life. I was very glad and pleased, that this phone call turned her negative thoughts into very positive ones! I believe what I did at the time seemed like a piece of cake to me, but I was a powerful thing happening for her. Hence, now I know the reason why people always said keep in touch, because with this connection I made a huge influence on a person unconditionally and unknowingly. In other words, I am glad that I am a human being, because I can use my kindness for people who need help, and make a real difference.